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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) of more than 27, given that they also suffer from weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and possess at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes showed that patients had a typical weight loss of 4.1% in contrast to participants who have been given placebos) after a 12- month period, while another study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to lose weight naturally can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people that go through it you should err to the side of caution and let the FDA do its job and demand some study be done so that the public is aware of the side effects and hazards of the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on his or her medications.

    Researchers found out that participants using this drug for the year, dropped excess weight within one month and have kept the weight off through the 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more effective and safer.

    Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is now popular may be the fact that at the time of right now there are no long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be authorized by the FDA.

    Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug could also raise hypertension and heart rate, and must not be used in people who have a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high hypertension, along with by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

    BioCorRx, Inc.'s naltrexone implant is no bigger than a thumb and it is inserted underneath the patient's skin through a 30-minute, noninvasive outpatient procedure created by a medical expert. The implant is administered as part of BioCorRx, Inc.'s Start Fresh Program that is distributed in several states by independent rehabilitation facilities.